C141
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C141
Sigma
CGS-21680 hydrochloride hydrate
solid
| Synonym: | 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate |
| CAS Number: | 124182-57-6 (anhydrous) |
| Linear Formula: | C23H29N7O6 · HCl · xH2O |
| Molecular Weight: | 535.98 (anhydrous basis) |
| MDL number: | MFCD11045878 |
| PubChem Substance ID: | 24277698 |
Description
| Caution | Hygroscopic |
| Legal Information | Manufactured and sold in the USA with the exclusive permission of Novartis Pharma AG, U.S. Patent 4,968,697. |
| Biochem/physiol Actions | Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | desiccated |
| color | white |
| solubility | DMSO: >10 mg/mL |
| 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL | |
| Gene Information | human ... ADORA2A(135), ADORA2B(136) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Jarvis, et al., [3H]CGS 21680 a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. J. Pharmacol. Exp. Ther. 251, 888, (1989) Abstract |
| Phillis, et al., The selective adenosine A2 receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res. 509, 328-330, (1990) Abstract | |
| Levens, et al., Renal actions of a new adenosine agonist CGS 21680A selective for the A2 receptor. J. Pharmacol. Exp. Ther. 257, 1005, (1991) Abstract |
